Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients
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چکیده
منابع مشابه
5-Fluorouracil toxicity and dihydropyrimidine dehydrogenase enzyme: implications for practice.
5-fluorouracil (5-FU) is a fluorinated pyrimidine analog, which is commonly used in combination chemotherapy for treating solid tumors. Dihydropyrimidine dehydrogenase plays an important role in catabolism and clearance of 5-FU. Any alteration in that sequence of enzymatic activity can lead to toxicity and even death in some patients. The most common loss of a functional allele of the dihydropy...
متن کاملDihydropyrimidine dehydrogenase activity: prognostic partner of 5-fluorouracil?
5-FU is one of the most commonly prescribed anticancer agents having notable activity in the treatment of cancers arising from the breast, gastrointestinal tract, and head and neck. The metabolism, mechanisms of action and resistance, and pharmacokinetics of 5-FU have been extensively investigated since its synthesis over 4 decades ago. Despite a longstanding knowledge of the metabolic pathways...
متن کاملDihydropyrimidine dehydrogenase activity correlates with fluorouracil sensitivity in breast cancer.
UNLABELLED The fluoropyrimidine drug fluorouracil (FU) is one of the most frequently prescribed chemotherapeutic drugs for the curative and palliative treatment of various cancer patients. The identification of biological factors associated with tumors either responsiveness or resistance to FU chemotherapy, including FU, is increasingly being recognized as an important field of clinical cancer ...
متن کامل5-Fluorouracil toxicity-attributable IVS14 + 1G > A mutation of the dihydropyrimidine dehydrogenase gene in Polish colorectal cancer patients.
DPYD gene encodes dihydropyrimidine dehydrogenase which is the initial and rate-limiting enzyme in the metabolism of 5-fluorouracil (5-FU). The aim of our study was PCR-RFLP based-genetic testing for the most common 5-FU toxicity-attributable IVS14 + 1G > A DPYD mutation (DPYD(*)2A) in 252 Polish colorectal cancer (CRC) patients treated with this adjuvant chemotherapeutic regimen after surgery....
متن کاملDihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance.
DPD (also known as dihydrouracil dehydrogenase, dihydrothymine dehydrogenase, and uracil reductase; EC 1.3.1.2) is the initial enzyme and the rate-limiting step in the pyrimidine catabolic pathway (1). Studies over the past two decades have demonstrated that DPD is an important regulatory enzyme in the metabolism of both the naturally occurring pyrimidines uracil and thymine as well as the canc...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2001
ISSN: 0923-7534
DOI: 10.1023/a:1012294617392